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PMID: 31905166 J Mol Med (Berl) Tyrosine hydroxylase as a therapeutic target: insights from adrenergic nerve and TNBC cell interactions

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This might be due to the restricted quantity of BER that can be captured in the phospholipid layer of anionic liposomes besides, the hydrophilic drug is typically encapsulated with low efficiency due to the presence of a large volume of external aqueous hydration medium, So, very little content of hydrophilic drug can be entrapped within the aqueous core of the liposome [75]

Luo Y, Yang Z, Yu Y, Zhang P