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If you have or have ever had Leber's hereditary optic neuropathy (slow, painless loss of vision, first in one eye and then in the other eye)

Postmenopausal osteoporosis (OVX) rat model: After 12 weeks of AOD 9604 treatment, the number of osteoclasts decreased by 35%, CTX levels decreased by 40%, and bone resorption rate decreased by 50%

Numbness or tingling sensations Pain in the hands and feet Weakness or fatigue Risk Factors for Developing B12 Deficiency Neuropathy Some people are more likely to get nerve damage from B12 shortage

This escalation should only occur if the lower dose is well-tolerated and additional benefit is needed to achieve treatment goals