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These are the same harmful compounds found in traditional tobacco and are major causes of cancer and cellular damage over time. He adds that many patients arriving at clinics suffer from severe coughing, hoarseness, dark or yellow phlegm, and in some cases have been diagnosed with pre-cancerous lesions on the vocal cords

Tolerance Over time, the brain becomes accustomed to the presence of nicotine, leading to tolerance

For comparison, direct (nonmodeled) estimates from the National Health Interview Survey (NHIS) [34], a nationally representative household survey, are also plotted

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With more time, we will gain a better understanding of the addictiveness, harmful effects, and adverse health conditions that will arise as a result of chronic EC and alcohol dual use