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The next step will be tests to look for signs of the H

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M iR - 135b can also bind to its own regulator ( IL - 1 receptor - 1 ), as well as its downstream effector, Caspase-1, in an attempt to stop further expansion of the inflammatory process by other potent cytokines, such as IL - 1 , implying that these molecules self-regulate in a negative feedback loop [183]