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Key symptoms that may indicate liver problems include: Jaundice : Yellowing of the skin or whites of the eyes, indicating elevated bilirubin levels Dark urine : Tea-colored or cola-colored urine, particularly when accompanied by pale stools Persistent abdominal pain : Especially right upper quadrant discomfort that doesn't resolve Unexplained fatigue : Severe tiredness disproportionate to activity level Nausea and vomiting : Persistent symptoms not attributable to the medication's known gastrointestinal effects Loss of appetite : Beyond the expected appetite suppression from the medication Easy bruising or bleeding : Suggesting impaired hepatic synthesis of clotting factors Urgent medical attention is needed for: Severe right upper quadrant pain with fever Confusion or disorientation Rapidly worsening jaundice Persistent vomiting It's important to distinguish between the common gastrointestinal side effects of these medicationssuch as nausea, vomiting, and diarrhea, which typically occur early in treatment and improve over timeand symptoms potentially indicating hepatic dysfunction