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Do not use more than 64 sprays per day this is equivalent to 4 sprays per hour for 16 hours

9 The guideline states that every contact with a pregnant woman, including all pre-conceptual care meetings, routine antenatal appointments, and chance encounters count are a valuable opportunity to intervene with pregnant smokers and encourage them to quit

Deaths and serious cardiovascular events occurring over the 52 weeks of the study (treatment emergent and non-treatment emergent) were adjudicated by a blinded, independent committee

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