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This pathway is frequently hijacked in CRC, serving as a major protective mechanism against the cytotoxicity of ROS-inducing chemotherapeutic agents such as 5-FU and oxaliplatin

Reducing obesity may decrease some of those impacts, he said

For instance, butyrate, an SCFA produced by certain gut bacteria, supports the integrity of the intestinal barrier and exerts anti-inflammatory effects (Guo et al., 2023