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This reverse action utilizes the calf muscles, core, and to some extent, the quadriceps in a unique manner

Inhale: Place the mouthpiece to your lips and draw gently

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The nicotine metabolite ratio (NMR), which reflects the ratio of the nicotine metabolites trans-3'-hydroxycotinine to cotinine, is a genetically informed biomarker that has been proven to predict smokers nicotine dependence, likelihood of achieving smoking cessation, and response to various FDA-approved cessation treatments, enabling personalized smoking cessation therapy 6,7