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Of these, 16 randomized controlled trials were included in the final analysis ( Table 1
Dods, R
Reprod Biol Endocrinol 21:37
Some experienced users reduce dose or frequency once they reach a desired pigmentation level, essentially shifting from PKdriven (pharmacokinetic) thinkinghow long is it in my blood?to PDdriven (pharmacodynamic) thinkinghow stable is my tan and how little do I need to maintain it? No matter the schedule, from a safety perspective, slow titration, long gaps between dose changes, and strict vigilance over mole changes or systemic side effects are minimum safeguards
In summary, Antigen-specific immunotherapy (ASI) may restore a self-tolerance immune system targeting pancreatic cells and ASI remains a promising approach in pursuit of a cure for T1D
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