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Left unmanaged, this imbalance is what's called oxidative stress , and it's been linked to everything from premature skin ageing to long-term organ strain

A study published in the journal Neurochemical Research in 2013 found that chlorogenic acid enhanced memory and stopped harmful enzymes that can lead to cognitive decline (x)

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However, if the purpose of the drug is to be taken up by the liver, then first-pass metabolism may be irrelevant (the drug is still metabolized into hepatic glutathione, which is what matters)