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Results Metabolic effects of GLP-1R agonismGIPR antagonism in DIO Vgat-Gipr KO mice We recently showed that loss of Gipr in Vgat -expressing GABAergic neurons renders DIO mice resistant to weight loss and inhibition of food intake by GIPR agonism 14

PLoS Pathog 11(7):e1005032 Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W (2017) Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity

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By removing excess fat, it enhances the natural contours of the waistline and improves the overall balance of the midsection