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Study endpoints include epithelial-barrier function, tight-junction protein expression, inflammatory signaling, and mucosal tissue remodeling in models of intestinal inflammation, increased permeability, and chemically induced gastrointestinal injury

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The IC model was established in female Sprague-Dawley rats using cyclophosphamide injection, while the test group was injected with a mixture of cyclophosphamide and shionone solution

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