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Research has shown that smoking and exposure to secondhand smoke can significantly increase the risk of developing plaque buildup in the arteries, a condition known as atherosclerosis

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NAFLD itself exists on a spectrum, ranging from simple steatosis (fat accumulation alone) to non-alcoholic steatohepatitis (NASH), where inflammation and liver cell damage occur alongside fat accumulation

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Evidence from experimental rodent models suggests a direct association between exposure to NNN and NNK and the induction of oral tumors, supporting their biological plausibility as key drivers of oral cancer risk (31, 32)