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However, because cigar smokers typically do not inhale and smoke cigars far less frequently, they often avoid the rapid nicotine highs and dependency that cigarette smokers experience

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A chemically diverse mixture of pro-inflammatory, oxidative and carcinogenic factors found in tobacco smoke has a number of different, sometimes contradictory effects

Although both hybrid and mature ciliated cells increased MUC5AC expression with smoking, mature ciliated cells uniquely activated many genes involved in xenobiotic metabolism, interferon-gamma signaling, and response to oxidative stress (Fig