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Compared to placebo, first line use of SGLT2i significantly reduced glycosylated hemoglobin type A1C (HbA1c) (MD: -0.72), weight (MD: -1.32) and fasting plasma glucose (FPG) (MD: -27.05) levels

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Addition of R-lipoic acid increases ATP synthesis and aortic blood flow during reoxygenation after hypoxia while S-lipoic acid had no effect on ATP synthesis and improved blood flow at only 10-fold the effective dose of R-lipoic