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In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) clinical trial and the Semaglutide and Cardiovascular outcomes in patients with type 2 diabetes (SUSTAIN-6) clinical trial, treatment with liraglutide or semaglutide compared with placebo resulted in fewer patients experiencing a composite cardiovascular outcome and decreased risk of CKD development and progressionbenefits mainly driven by the reduction in new-onset macroalbuminuria (2, 3, 5)