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It is hoped that ongoing trials like SUMMIT, which is investigating tirzepatide in participants with HFpEF and obesity, will provide more evidence on incretin-based medications in HFpEF

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EMPA compared to DPP-4i, was associated with 27-47% lower risk of hospitalization for heart failure (HHF), stroke, all-cause mortality (ACM), and two composite outcomes: HHF plus ACM

The study enrolled 54 healthy patients who received 5 mg of oral semaglutide daily for the first 5 days, followed by 10 mg daily for the remaining 5 days with or without 40 mg of omeprazole taken daily for the 10-day duration of the study