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10.1016/j.jpba.2017.04.050 6 BeharR

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The toxic chemicals in tobacco cause the blood vessels to constrict, so the heart has to work harder to pump blood around the body

In animal models, mice were exposed for 60 weeks to the e-cigarette with a concentration of nicotine from 0 to 24 mg/mL showed endothelial dysfunction and an increase in endothelial ROS, in addition to a thickening of the vessel wall were dependent on nicotine concentration (186)