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Reinstatler L, Qi YP, Williamson RS: Association of Biochemical B-12 Deficiency With Metformin Therapy and Vitamin B-12 Supplements The National Health and Nutrition Examination Survey, 1999-2006

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First-generation GLP-1 receptor agonists necessitated once or twice-daily dosing, resulting in substantial peak-to-trough variations that caused inconsistent glycaemic regulation and heightened gastrointestinal adverse effects (Nauck and Meier 2019)