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2,3 However, most transcription factors are notoriously undruggable due to an intrinsic disorder in their structure owing to convex DNA binding interface and flatter protein binding interface, rendering difficulties in targeting their functional associations with DNA or proteins

Ramirez-Miranda A, et al

In a large year-long clinical trial, briakinumab was effective in the treatment of moderate-to-severe psoriasis

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Study participants were age -and sex-matched ( Figure 1B ) and all were infected with the Wuhan strain and recruited at ~12 months post the onset of acute infection ( Supplementary Table 1 )