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As in the case of paracetamol overdose, this type of injury occurs shortly after some threshold for toxicity is reached

Medical Pharmacology Chapter 2 General Principles: Pharmacokinetics Transition from first-order to zero-order kinetics is described by the Michaelis-Menten model of enzyme kinetics, which provides a mathematical description for saturable, capacity-limited elimination processes

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After 30 days the dose should be increased to 7 mg by mouth daily