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This indicated a decrease in GAPDH activity and a concomitant diversion of glucose into the oxidative phase of the pentose phosphate pathway (PPP), a metabolic shift that, upon oxidative stress, helps restore NADPH levels and cellular reducing potential (Figure 1)

The two active forms are produced on separate metabolic pathways and perform completely different functions

Another study shows that p53 may also be involved in ubiquitination-dependent regulation of ferroptosis

46 Examples include tinnitus secondary to otitis media, tympanic membrane perforation, tensor tympani or stapedius muscle spasms, 47 and tension tympanum syndrome

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