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This creates a feedback loop in which sleep impairments not only accelerate the aging process by promoting cellular senescence and DNA damage, but also elevate ROS levels, leading to the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum and increased activity of ROS generating enzymes such as NADPH oxidase, xanthine oxidase and phospholipase A2 (Xu et al., 2020)

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

10.1021/js980086i 156 ZhangY.BonzoJ

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