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What Ipamorelin does WELL: Stimulates pulsatile GH release with high selectivity Produces minimal ACTH, cortisol, and prolactin disruption even at doses exceeding 200 times the ED50 for GH release Has less impact on glucose metabolism compared to MK-677 Preserves natural GH rhythm, thanks to its short action window Where Ipamorelins evidence base falls short: No large-scale human body composition trials Limited direct evidence for muscle gain outcomes Sparse sleep architecture research Very limited long-term safety datasets in humans In spite of these downsides, the absence of large human trials does not automatically mean Ipamorelin is unsafe or ineffective

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If your insulin sensitivity is compromised, MK-677 is not the right starting point