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Assessment of mixed infections Seven 1a + 1b mixed subtypes were detected either with the GT Plus assay ( n = 2) and/or the GT II assay ( n = 6)

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To restore NAD + levels, ATM-deficient models were treated with NR, which stimulated PINK1-dependent mitophagy, reduced cytoplasmic DNA levels, and activated the NAD + -dependent SIRT1 signaling pathway, which in turn further promoted mitochondrial mitophagy and healthy morphology 111,288