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When fat is broken down, ketones are produced and build up

However, what truly reduces health risks is not the nicotine amount but the fact that IQOS avoids combustion

[64] Many devices lets the user use interchangeable components, which result in variations in the e-cigarette vaporized nicotine

A recent critical appraisal published in the journal Tobacco Control by Sophie Braznell and colleagues in the UK of the known published interventional clinical trials of these products does not inspire confidence in recommending them: Of the 40 identified interventional clinical trials assessing heated tobacco products (HTP), 29 were industry affiliated and 11 were independent

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