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Tirzepatide's dual-receptor mechanism makes it fundamentally different from single-action GLP-1 drugs like semaglutide

The peptide works by binding copper ions and acting as a signaling molecule

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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]