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Tirzepatide the approved label starts at 2.5 mg once weekly and escalates in 2.5 mg steps at intervals of at least four weeks, to a maintenance dose of up to 15 mg once weekly

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Interestingly, despite the presence of superoxide dismutase (SOD) ( k = 2.4 10 9 M 1 s 1 ) 36 , the resulting concentration of H 2 O 2 is significantly smaller than the concentration of superoxide, indicating that the model is able to respond well to a transient increase in ROS, maintaining low H 2 O 2 concentrations

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