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We modeled the patients quality of life using health state utility weights, where 0 signified death and 1 represented perfect health

Mean change in body weight from baseline to Week 52 was a secondary endpoint.* Statistically significant vs Januvia 100 mg PIONEER 3 study design 1,4 In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 1864 adult patients with type 2 diabetes on metformin alone or metformin with a sulfonylurea were randomized to RYBELSUS 3 mg (n=466), RYBELSUS 7 mg (n=465), RYBELSUS 14 mg (n=465), or Januvia 100 mg (n=467), all once daily

Early findings from that study suggest that treatment with Zepbound may lead to greater weight loss overall

Epidermal homeostasis: The role of the growth hormone and insulin-like growth factor systems

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