[24] In late February 2020, a CDC-authored article in the NEJM stated that the VAPI outbreak was "driven by the use of THC-containing products from informal and illicit sources." [25] [24] However, the CDC also stated, "Evidence is not sufficient to rule out the contribution of other chemicals of concern, including chemicals in either THC or non-THC products, in some of the reported EVALI cases." [26] In 2021, analysis of the aerosols from popular vape brands such as Juul and Vuse found "nearly 2,000 chemicals, the vast majority of which are unidentified." [27] [28] The CDC has stated that the THC cutting agent vitamin E acetate is very strongly implicated in VAPI, [29] but evidence was not sufficient to rule out a contribution from other chemicals of concern to VAPI as of January 2020
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1, 2026, manufacturers must: Submit applications for each product they want included on the state list Pay a $300 application fee (reduced to $150 for annual renewals) Ensure products have either: Received FDA marketing authorization, or Have a pending Premarket Tobacco Application (PMTA) that was submitted by the FDAs September 2020 deadline and remains under review Products with FDA marketing denial orders (MDOs) may qualify only if the denial has been stayed, rescinded, or vacated by a court To guarantee inclusion on the January list, applications must be submitted by October 9, 2025