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[74] Dosage The first factor, dosage, has been a truism since ancient times, or at least since Paracelsus who said, "Dose makes the poison." Some compounds are beneficial or pleasurable when consumed in small amounts, but harmful, deadly, or evoke discomfort in higher doses

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Season 22, Episode 8 The Fight Before Christmas In a Christmas dream sequence parodying The Polar Express, Otto operates a train and shovels marijuana leaves into the furnace to keep it going

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