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One major chemical is called nicotine

JC: Yeah

A December 2018 advisory from the Surgeon General lists the dangers: In addition to nicotine, the aerosol that users inhale and exhale from e-cigarettes can potentially expose both themselves and bystanders to other harmful substances, including heavy metals, volatile organic compounds, and ultrafine particles that can be inhaled deeply into the lungs. Moreover, adolescents who vape are more likely to smoke combustible cigarettes subsequently, as compared with peers who have never used e-cigarettes, according to a review and meta-analysis of studies that assessed the link between vaping and subsequent cigarette smoking

Primary packs are becoming more innovative due to strict regulatory requirements for labeling health warnings and tamper-evident features