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PMID: 34669960 Nat Plants2021 Feb;7(2):209-218

Specifically, IRPs binding to IREs at the 5-UTR suppress translation of ferritin, FPN1, and amyloid precursor protein (APP), while IRP binding at the 3-UTR stabilizes mRNAs of TfR1 and DMT1, thereby promoting iron uptake under conditions of deficiency (Mai et al., 2023)

Safety monitoring should include immunogenicity, endocrine panels for GH-axis agents, and pharmacovigilance reporting

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