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Knowing more about adverse experiences can help FDA identify concerning trends and causes or contributors for particular incidents or health or quality problems beyond those normally associated with tobacco product use

and appeal to relative risk (compared with cigarettes) as a rationale to allow marketing.127 Products claiming to contain synthetic nicotine (as opposed to nicotine derived from tobacco) have emerged in the past 23 years, largely in response to specific regulatory decisions as to what constitutes a tobacco product (eg, US FDA)

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others stress the unknown long-term effects and call for strong regulation to prevent youth uptake

Many smokers prefer keeping a carton at home for easy storage and access