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There was also concern that mutations caused by cigarette smoking would have irreversible long-term effects on the genetics of the population

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Smoking tobacco can start an asthma attack or aggravate an existing attack

After one year, 79 participants in the group assigned to use e-cigarettes (18%) and 44 participants in the group assigned to use nicotine-replacement therapy (9.9%) had quit cigarette smoking (as validated by a chemical breath test)