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Biochim Biophys Acta Mol Basis Dis (2017) 1863(5):106677

In some cases, these variations may be mild and temporary, but in others, they can be a sign of a more serious underlying medical condition

The specific upstream triggers of each disease (such as A, ischemia and hemorrhage) activate these common downstream pathological processes, which in turn are the direct upstream activators of the core ferroptosis machinery (iron overload, lipid peroxidation and antioxidant system depletion)

FAO, fatty acids oxidation