They work by trapping certain smoke chemicals inside tiny pores
teen smoking rates have dipped below 10 percent, but public health advocates worry that progress may soon level off, as other surveys suggest teens think light smoking is safe, and e-cigarette use is on the rise
2004;6:S3639

CHANTIX has also been studied in postmarketing trials including (1) a trial conducted in patients with chronic obstructive pulmonary disease (COPD), (2) a trial conducted in generally healthy patients (similar to those in the premarketing studies) in which they were allowed to select a quit date between days 8 and 35 of treatment (alternative quit date instruction trial), (3) a trial conducted in patients who did not succeed in stopping smoking during prior CHANTIX therapy, or who relapsed after treatment (re-treatment trial), (4) a trial conducted in patients with stable cardiovascular disease, (5) a trial conducted in patients with stable schizophrenia or schizoaffective disorder, (6) a trial conducted in patients with major depressive disorder, (7) a postmarketing neuropsychiatric safety outcome trial in patients without or with a history of psychiatric disorder, and (8) a trial in patients who were not able or willing to quit abruptly and who were instructed to quit gradually (gradual approach to quitting smoking trial)

This can lead to the weakening and breaking down of the surface area of the lungs, which makes it lose its elasticity thus making it unable to empty easily