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Up to now, in addition to mitochondrial oxidative stress, many other cellular processes, including phase I/phase II metabolism, endoplasmic reticulum stress, autophagy, sterile inflammation, microcirculatory dysfunction, and liver regeneration, have been identified to be involved in the pathogenesis of AILI, providing new targets for developing more effective therapeutic interventions against APAP-induced liver injury

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So you learn all that throughout the book

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ROS also play important roles in the activation and regulation of innate and adaptive immunity, including respiratory bursts and inflammasome activation 18,19