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In addition, DPP-4 cleaved GLP-1(7-36)amide and GLP-1(7-37) to form GLP-1(9-36)amide or GLP-1(9-37), low-affinity ligand of GLP-1 receptor and nonprimary role in regulating glucose metabolism (98101)

Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field

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Its well established that muscle health is a key predictor of longevity, and muscle preservation should be a strategy we all focus on as we try to optimize our health

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