In the face, for instance, direct exposure of the skin to smoke induces high levels of oxidative stress associated with the skin barrier disruption, whereas in the less exposed areas such as the volar forearm, the compensatory processes may maintain the barrier function
Smokers may take larger or more frequent puffs, block the ventilation holes, or smoke more cigarettes to maintain their nicotine intake, ultimately leading to similar or higher actual nicotine and tar exposure
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It provides policymakers with a framework for anticipating and potentially mitigating the unintended consequences of tax and regulatory decisions