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It is of particular interest that these markers were also increased by exposure to cigarette smoke, but not by exposure to cMRTP aerosol, in a mouse model of disease [41]

(h) The Commissioner of Food and Drugs, either on his or her own initiative or in response to a petition submitted pursuant to part 10 of this chapter, may issue a proposal to establish or amend a reference amount in paragraph (b) of this section

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