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The DOJ has ordered KT&G to submit documents related to the products in question, though no sanctions have yet been imposed. The main accusation against KT&G involves the omission of information about harmful substances, including diacetyl and levulinic acid, from the data submitted to the FDA regarding their cigarettes

We summarize how smoking-related alteration of the cytokine balance, the increased risk of infections (the possibility of cross-reactivity) and modifications of autoantigens by citrullination may contribute to the development of rheumatoid arthritis

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