american diabetes association history of pancreatitis glp-1 Agonists and Risk: Reassessing an Old Concern with New Evidence Does Semaglutide Cause Pancreatitis? Evidence

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Cells were washed with PBS before image acquisition by confocal microscopy (DMI6000B, Leica Microsystems, Wetzlar, Germany)

We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

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