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Recent studies have demonstrated a link between hypoxia and sterile inflammation via IL-1 priming of the NLRP3 inflammasome [67,68,69,70,71]

They want to put the products, used by an estimated 1.3 million people in Britain by next year, on the same legal basis as gums, patches and mouth sprays aimed at helping smokers to quit but the industry says the expensive process of licensing would help force alternatives to tobacco off the shelves