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The scoring standard for IHC staining adopted the immunoreactive score (IRS) system [15, 16], with the specific rules as follows: the staining intensity of GGCT protein was classified into four grades, where a score of 0 indicated no staining signal, 1 indicated weak positivity, 2 indicated moderate positivity, and 3 indicated strong positivity

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Survodutide's Phase 2 data showed GI events in 75% of treated patients, which may partly reflect the rapid dose escalation used in early trials

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oz of water once daily, or as otherwise directed by a healthcare practitioner