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We meanwhile confirmed that hexarelin induced down-regulation of IL-1 expression and up-regulation of IL-1Ra expression in I/R myocardium, which could be neutralized by the GHSR antagonist [D-Lys3]-growth hormone releasing peptide-6 ([D-Lys3]-GHRP-6)

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These topline findings position orforglipron as a compelling, patient-friendly option in diabetes management pending full publication and regulatory review

doi: 10.4049/jimmunol.1004237 7 BauerS.KirschningC

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