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But it does not stop there: The FDA mandates that all diabetic medications have dedicated trials solely for the purpose of proving cardiac safety

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Jones IR, Owens DR, Luzio S, Williams S, Hayes TM

Long-term effects have not been studied in humans or even in animals beyond short-term protocols

This is the standard retatrutide titration approach and is relevant because proper titration may solve the same problems that microdosing attempts to address