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The SELECT cardiovascular outcomes trial (Lincoff et al., 2023, New England Journal of Medicine) enrolled 17,604 adults with obesity and established cardiovascular disease no diabetes, and demonstrated a 20% reduction in major adverse cardiovascular events (MACE) with 2.4mg semaglutide versus placebo

Patients who lose 1015% of body weight often report improved energy and better thyroid hormone absorption, though thyroid hormone dosing should be monitored and adjusted by a physician as weight changes

See our peptide storage guide

If a dosage is missed, take it as soon as possible and within 5 days

Most patients benefit from increasing to higher maintenance doses