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Nausea and diarrhoea were the most common side effects which were transient and improved with time, with less than 5% TLDR summary: The SUSTAIN 6 trial looked at the cardiovascular outcomes (cardiovascular death, heart attack and stroke) in high cardiovascular risk diabetic patients being treated with semaglutide versus placebo- with the results showing a significant 26% reduction in cardiovascular death, heart attack and stroke in patients being treated with semaglutide The SUSTAIN 6 trial published in the New England Journal of Medicine showed that in patients with type 2 diabetes who were at high cardiovascular risk