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Surgical Treatments Results: Most dramatic and comprehensive improvement Longevity: Long-lasting results that can maintain improvement for many years Downtime: Requires recovery time (typically a few weeks) Ideal Candidate: Patients with moderate to severe sagging or significant excess skin Non-Surgical Treatments Results: Subtle to moderate improvement Longevity: Temporary

Interventions Garetosmab Trevogrumab Trial Overview The study tests trevogrumab alone or combined with garetosmab and semaglutide in two parts: Part A focuses on safety in healthy individuals

141719) antibodies were purchased from BioLegend (San Diego, CA, USA)

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Some peptides may also require monitoring during treatment.